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Venetoclax is a BCL-2 inhibitor used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) as well as acute myeloid leukemia (AML). Venetoclax selectively inhibits the anti apoptotic protein BCL-2, which is overexpressed in chronic lymphocytic leukemia (CLL) cells and acute myeloid leukemia (AML) cells. BCL-2 mediates tumor cell survival and is associated with chemotherapy resistance. Venetoclax directly binds to BCL-2 protein, replacing pro apoptotic proteins and restoring the apoptotic process.
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