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Drug interactions of Venetoclax

1.Effects of Other Drugs on venetoclax

Concomitant use with a strong or moderate CYP3A inhibitor or a P-gp inhibitor increases venetoclax Cmax and AUC0-INF, which may increase venetoclax toxicities, including the risk of TLS.venetoclax

2.Effect of venetoclax on Other Drugs

Warfarin

Concomitant use of venetoclax increases warfarin Cmax and AUC0-INF,which may increase the risk of bleeding. Monitor international normalized ratio (INR) more frequently in patients using warfarin concomitantly with venetoclax.

P-gp Substrates

Concomitant use of venetoclax increases Cmax and AUC0-INF of P-gp substrates, which may increase toxicities of these substrates. Avoid concomitant use of venetoclax with a P-gp substrate. If a concomitant use is unavoidable, separate dosing of the P-gp substrate at least 6 hours before venetoclax.

from FDA，2022.06