What drugs does venetoclax interact with?

Release date: 2024-08-14 17:23:40     Recommended: 123

Venetoclax is the world's only approved selective inhibitor of Bcl-2 that can induce spontaneous apoptosis of cancer cells by specifically binding to Bcl-2 protein and reduce the impact on healthy cells.

What drugs does venetoclax interact with?

Drug interactions are organized as follows:

1. The effect of other drugs on venetoclax

Concomitant use with strong or moderate CYP3A inhibitors or P-gp inhibitors increases plasma concentrations (Cmax and AUC0-INF) of venetoclax, which may increase the risk of toxicity and increase the likelihood of tumor lysis syndrome (TLS).

2. Effect of venetoclax on other drugs

warfarin

Venetoclax increases blood levels of warfarin, which may increase the risk of bleeding. Patients taking both drugs require more frequent monitoring of the international normalized ratio (INR).

Will venetoclax be used for special populations?

In other words, special drug users should be aware of the drug.

1. Renal insufficiency

Patients with reduced renal function are at increased risk of tumor lysis syndrome (TLS) when taking venetoclax and require more rigorous prevention and monitoring. Patients with mild to severe renal insufficiency generally do not need to adjust the dose.

2. Pregnant women

Venetoclax may cause embryo-fetal damage to pregnant women. There are currently no data on the risk of venetoclax in pregnant women, and it is recommended to avoid it during pregnancy.

What are the adverse effects of venetoclax?

Patients may experience a range of adverse effects while receiving venetoclax.

1. Cough

Cough may be caused by an infection or medication side effects, and persistent cough may require further evaluation and symptomatic treatment.

2. Musculoskeletal pain

Patients may experience pain in the joints, bones, or muscles, often with pain medication or physical therapy to relieve symptoms.

3. Nausea

Persistent nausea may affect the patient's appetite and nutritional intake. Anti-nausea medications or dietary modifications may help.

[Warm tips] During the treatment, in addition to maintaining vigilance and timely feedback to the doctor, patients should also follow the doctor's medication guidance and do not adjust the drug dosage or change the medication mode without permission. Maintaining good lifestyle habits and attitude, and actively cooperating with treatment, are also important factors in promoting recovery.