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Drug interactions of Pralsetinib

Avoid co-administration of pralsetinib with strong or moderate CYP3A inhibitors, P-gp inhibitors, or agents that are both P-gp inhibitors and strong/moderate CYP3A inhibitors. If co-administration cannot be avoided, the dose of pralsetinib should be reduced. Avoid co-administration of pralsetinib with strong or moderate CYP3A inducers. If co-administration cannot be avoided, the dose of pralsetinib should be increased.

from FDA，2024.03