Side Effects of Enasidenib

Release date: 2026-03-24 17:00:21     Recommended: 152

Enasidenib helps restore the normal differentiation of leukemia cells by inhibiting the activity of mutant IDH2 enzymes. During treatment, it may also affect the function of normal cells, leading to a range of adverse reactions.

Severe Adverse Reactions

Seek immediate medical attention if any of the following side effects occur while taking Enasidenib:

More Common Side Effects

Nervous system: Restlessness, confusion, dizziness, syncope, lightheadedness, loss of consciousness, seizures, severe drowsiness, abnormal lethargy/sluggishness/tiredness/weakness/fatigue.

Cardiovascular system: Cyanosis of the lips/nails/skin, chest pain, rapid heartbeat.

Respiratory system: Cough, cough with pink frothy sputum, dyspnea, shortness of breath/difficulty breathing/with rales, irregular/faster/slower/superficial breathing, tachypnea/superficial breathing.

Digestive system: Nausea.

Musculoskeletal system: Bone pain, muscle or joint pain, muscle spasms.

Skin, mucous membranes/edema: Pale skin, yellowing of the skin or eyes, swelling of the neck/inguinal/axillary regions, swelling of the arms/feet/calves, swelling of the face/ankles/hands.

Psychological system: Depression, hostility, irritability.

Systemic and infection-related symptoms: Chills, fever, general malaise, increased sweating, sore throat.

Urinary system: Decreased urine output.

Other Side Effects

Consult a healthcare professional if any of the following side effects persist, cause distress, or if you have any related questions:

More Common Side Effects

Altered taste, decreased appetite, diarrhea, loss of taste, vomiting.