Side Effects of Enasidenib

Release date: 2026-03-24 17:00:21     Recommended: 4

Enasidenib helps restore the normal differentiation of leukemia cells by inhibiting the activity of mutant IDH2 enzymes. During treatment, it may also affect the function of normal cells, leading to a range of adverse reactions.

Severe Adverse Reactions

Seek immediate medical attention if any of the following side effects occur while taking Enasidenib:

More Common Side Effects

Nervous system: Restlessness, confusion, dizziness, syncope, lightheadedness, loss of consciousness, seizures, severe drowsiness, abnormal lethargy/sluggishness/tiredness/weakness/fatigue.

Cardiovascular system: Cyanosis of the lips/nails/skin, chest pain, rapid heartbeat.

Respiratory system: Cough, cough with pink frothy sputum, dyspnea, shortness of breath/difficulty breathing/with rales, irregular/faster/slower/superficial breathing, tachypnea/superficial breathing.

Digestive system: Nausea.

Musculoskeletal system: Bone pain, muscle or joint pain, muscle spasms.

Skin, mucous membranes/edema: Pale skin, yellowing of the skin or eyes, swelling of the neck/inguinal/axillary regions, swelling of the arms/feet/calves, swelling of the face/ankles/hands.

Psychological system: Depression, hostility, irritability.

Systemic and infection-related symptoms: Chills, fever, general malaise, increased sweating, sore throat.

Urinary system: Decreased urine output.

Other Side Effects

Consult a healthcare professional if any of the following side effects persist, cause distress, or if you have any related questions:

More Common Side Effects

Altered taste, decreased appetite, diarrhea, loss of taste, vomiting.