Your Health, We Care
Release date: 2026-03-26 16:59:57 Recommended: 3
Larotrectinib may cause a range of side effects and adverse reactions, varying from mild to severe. Understanding these potential side effects is crucial for patients undergoing treatment or considering the use of larotrectinib, as well as for their families.
Back pain, constipation, decreased appetite, difficulty moving, weight gain, joint pain or swelling, muscle stiffness, pain in the arms or legs, nasal congestion.
Fatigue or loss of strength.
Serious Side Effects
Nervous System: Forgetfulness, disorientation in time/place/person, dizziness, headache, memory loss, memory impairment, speech or speaking difficulties, numbness or tingling in the hands and feet, difficulty concentrating, drowsiness or unusual sleepiness, falls.
Digestive System: Black, tarry stools, loss of appetite, mouth ulcers/sores/white patches.
Urinary System: Bladder pain, blood in urine or cloudy urine, difficulty or burning/painful urination, frequent urge to urinate, lower back or side pain, pain or difficulty urinating.
Cardiovascular System: Chest tightness, unusually slow or fast heartbeat, swelling of the face, arms, hands, lower legs, or feet, pale skin.
Respiratory System: Cough, difficulty breathing, sore throat, chills, fever.
Mental and Emotional Symptoms: Low mood, fear/tension, sadness or emptiness, holding onto false beliefs that cannot be corrected by facts, irritability, loss of interest or pleasure, nervousness, visual/auditory/tactile hallucinations, unusual excitement/tension/restlessness, insomnia.
Systemic and Metabolic Effects: Unusual tiredness or weakness, rapid weight gain, abnormal weight loss or gain, unusual bleeding or bruising.
Cardiovascular System: Chest pain or discomfort, rapid heartbeat, irregular heartbeat, swelling of the face, ankles, or hands.
Nervous System: Confusion, fainting, lightheadedness, loss of consciousness, seizures, difficulty moving or walking.
Digestive System: Diarrhea, dry mouth, heartburn, indigestion, severe abdominal pain/cramping/burning sensation, nausea, vomiting, severe and persistent vomiting (vomit resembling coffee grounds).
Urinary System: Decreased urine output.
Skin and Appendages: Itching, pain, redness, swelling, tenderness, or warmth of the skin, increased skin wrinkling, yellowing of the skin or eyes.
Respiratory System: Shortness of breath, shallow breathing.
Systemic and Metabolic Effects: Increased thirst, sunken eyes.
