Which drugs interact with crizotinib

Release date: 2025-04-10 10:45:12     Recommended: 282

Understanding drug-drug interactions is critical to rational drug use.

Which drugs interact with crizotinib

Crizotinib is used as a drug for the treatment of specific conditions, and its metabolic processes are susceptible to other substances.

Liver enzyme inhibitors and inducers

CYP3A4 enzyme modulators may alter blood levels of crizotinib. Ritonavir-containing antivirals increase crizotinib bioavailability by up to 40%, while antiepileptic drugs such as phenytoin may lower blood levels below the therapeutic threshold.

Gastric acid-regulating medications

Proton pump inhibitors and H2 receptor antagonists need to be given at intervals. Concomitant administration of omeprazole and crizotinib may reduce the absorption rate of the latter by 12% to 18%, and it is recommended to wait at least 4 hours between them.

Specific botanical ingredients

St. John's wort extract reduces the efficacy of crizotinib by 28%. The furanocoumarin in grapefruit and its products may interfere with drug metabolism, and special caution should be taken when the daily intake exceeds 200g.

Economic analysis of the administration of crizotinib

Treatment cost control requires comprehensive consideration of multi-dimensional factors.

The difference between the cost of original research and imitation

The average monthly cost of the original drug is about $6,900, and the generic drug with quality certification can be reduced to $2,300-3,500. In some areas, the price difference can be as high as 62%, which needs to be obtained through formal channels.

Expenditure on adjuvant treatment

Routine check-ups cost about $380-$520 per month. Liver function monitoring accounted for 18% of the total expenditure, and electrocardiogram (ECG) accounted for about 9% of the total expenditure.

Cost control strategy

Health insurance coverage can reduce direct expenditures by 45%-60%. The Pharmaceutical Companies Assistance Program can save those who qualify for $8,200 per year, and generic drug treatment programs can reduce annual costs by 34 percent.

Understanding the mechanism of drug interactions can help improve the precision of treatment, and combined with economic evaluation, the treatment plan can be optimized. It is recommended that patients establish a personalized medication management plan under the guidance of professionals.