What are the drug interactions of crizotinib

Release date: 2025-04-10 10:17:31     Recommended: 46

Understanding the characteristics of the drug and the guidelines for its use can help improve the rationality of the treatment plan.

What are the drug interactions of crizotinib

Drug combinations may have an important impact on treatment outcomes.

Effects of the metabolic system of liver enzymes

CYP3A enzyme inducers such as rifampicin may reduce blood concentrations of crizotinib by approximately 50%, while inhibitors such as ketoconazole may increase their concentrations by a factor of 2.4. Liver function indexes should be monitored regularly during use.

Restrictions on the use of gastric acid regulators

Proton pump inhibitors reduce crizotinib bioavailability by 46%. It is recommended that H2 antagonists be taken 10 hours apart and antacids should be taken 4 hours apart.

Synergistic effects of cardiovascular drugs

When combined with QT interval prolongation drugs, the incidence of ECG abnormalities increased to 17%. Serum levels of digoxin may increase by a factor of 1.5, requiring adjustment of dosing intervals and enhanced ECG monitoring.

Practical points for standardizing medication

Scientifically managed medication regimens can reduce potential risks.

Cut-off value for dose adjustment

Patients with abnormal liver function require a 1/3 dose reduction when ALT exceeds the 3-fold upper limit. Grade 2 visual impairment should be suspended, and treatment should be resumed with 250 mg once a day after recovery.

Coping strategies for adverse effects

For 66% of patients with gastrointestinal reactions, it is recommended to take it in divided doses with food. Compression stockings may be considered in patients with peripheral edema, and diuretics should be evaluated for indications in severe cases.

Dosing regimens for special populations

The median clearance rate of elderly patients decreased by 22%, and blood concentration monitoring should be strengthened. For patients weighing less than 50 kg, it is recommended that the starting dose be adjusted to 200 mg twice a day, and tolerability should be dynamically assessed.

Clinical medication needs to comprehensively evaluate the individualized characteristics, and maximize the treatment benefit through regular testing and program optimization. Full communication between the medical team and the patient plays a key role in establishing a standardized medication system.