Your Health, We Care
Release date: 2024-08-23 17:41:03 Recommended: 116
The combination of Alpelisib and fulvestrant specifically targeted patients with advanced breast cancer with HR/HER2- and PIK3CA mutations significantly prolongs progression-free survival.
In terms of market price, the Laos Lucius version of Alpelisib is 150mg*28 tablets, and the price is about 1755 yuan; The India export version provides a combination of 200mg*14 capsules and 150mg*28 capsules, and the price is about 3900 yuan; In contrast, the price of the Hong Kong export version of 150mg*56 capsules is higher, about 43,800 yuan.
Prices vary in the market, and patients can choose the version that suits their needs. Patients should also understand the actual effects of these drugs in clinical treatment before purchasing them.
In terms of therapeutic effect, Alpelisib effectively inhibited tumor cell proliferation and significantly prolonged the progression-free survival of patients.
Of the 341 patients with PIK3CA mutations, approximately 99% (336) had PIK3CA mutations confirmed in tumor tissues with FDA-approved kits. Of the 336 confirmed patients, about 56% (177) also had PIK3CA mutations detected in plasma specimens.
The primary efficacy includes progression-free survival (PFS) and overall response rate (ORR), with patients with PIK3CA mutations performing better in PFS. OS (overall survival) did not differ significantly between the Alpelisib plus fulvestan and placebo groups, but it still showed some therapeutic advantage in patients with PIK3CA mutations.
In patients with PIK3CA mutations, apellix showed good efficacy, but some adverse effects were also observed during the course of treatment. The specifics of these adverse effects will be further explored below.
There are some adverse effects that may occur when using Apellix, and understanding them can help patients better monitor their condition.
Medications can cause blood sugar levels to rise, increase the risk of diabetes, or worsen existing diabetes conditions. Symptoms of hyperglycemia include frequent thirst, frequent urination, and weight loss.
The use of drugs may affect kidney function, causing creatinine levels to rise. This change may indicate impaired renal filtration and require regular monitoring of kidney function.
Understanding these common adverse effects can help better manage the course of treatment. If severe or persistent symptoms occur, you should contact your doctor promptly for appropriate measures.
[Warm tips] During the use of the drug, pay attention to the changes in the body and carry out the necessary relevant examinations regularly.
