Your Health, We Care

Home > Drug List > Alpelisib > Drug interactions of Alpelisib

What interactions can occur with other medications

Release date: 2024-12-23 13:37:41     Recommended: 80

Apellix is a drug used to treat certain types of breast cancer, and its use, storage, and drug interactions require strict attention from patients and health care providers.

What interactions can occur with other medications

Understanding how apelix interacts with other drugs is critical to ensuring safe medication for patients.

Interaction with CYP3A4 inducers

Strong CYP3A inducers can significantly reduce the plasma concentration of apellix and reduce its efficacy. It should be avoided in combination with drugs such as rifampicin, rifapentine, phenytoin, carbamazepine, barbiturates, and St. John's wort. If this is not avoidable, the dose of apellix should be increased appropriately.

Interaction with BCRP inhibitors

Co-administration with BCRP inhibitors may increase the concentration of apellix and increase the risk of toxicity. The use of BCRP inhibitors in patients receiving apellix should be avoided. If necessary, monitor closely for adverse effects.

Interaction with CYP2C9 substrates

Combination with CYP2C9 substrates (e.g., warfarin) reduces plasma concentrations and activity of these drugs. When apellix is used in combination with CYP2C9 substrates, changes in plasma concentrations of CYP2C9 substrates need to be closely monitored.

What to pay attention to when storing Apelis

Proper storage is essential to maintain the stability and efficacy of apellimax.

Temperature control

Apellix should be stored in an environment between 20°C and 25°C with a permissible temperature deviation of 15°C to 30°C. Avoid extreme high or low temperature environments to avoid affecting the structure and efficacy of the drug.

Moisture and moisture resistant

Choose a dry, well-ventilated place to store apellix to prevent the medicine from getting wet. Humidity changes can have a negative impact on the stability of the drug.

Store away from light

Apellix should be kept away from direct sunlight, which may adversely affect the stability of the drug. It should be protected from light or in an opaque container.

How to avoid drug interactions between Apellix and other medications

Reasonable measures can be taken to effectively avoid interactions between apellix and other drugs.

Learn about drug interactions

Before using apellix, patients should read the package insert carefully for information on drug interactions. At the same time, medical staff should also provide adequate medication guidance to patients.

Avoid concomitant use of contraindicated medications

Patients should avoid concomitant use of contraindicated medications that interact with apellix. If it must be used, the medication regimen should be adjusted under the guidance of a doctor.

Monitor closely for adverse effects

Patients should monitor their reactions closely while using apellix, and if they develop uncomfortable symptoms, they should seek medical attention and inform their doctor of the medication they are taking. Health care providers should also follow up patients regularly.

Apellix is an effective drug for the treatment of specific types of breast cancer, and its use, storage, and drug interactions require strict attention from patients and healthcare professionals. By understanding drug interactions, avoiding concomitant contraindications, and closely monitoring adverse reactions, patients can be ensured to take drugs safely and the treatment effect can be improved. At the same time, patients should also maintain good living habits and attitudes, actively cooperate with treatment, and strive for early recovery.