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The recommended dosage of Adagrasib is 600 mg orally twice daily until disease progression or unacceptable toxicity. Take Adagrasib at the same time every day with or without food. Swallow tablets whole. Do not chew, crush or split tablets. If vomiting occurs after taking Adagrasib, do not take an additional dose. Resume dosing at the next scheduled time. If a dose is inadvertently missed, it should be skipped if greater than 4 hours have elapsed from the expected dosing time. Resume dosing at the next scheduled time.
Reactions Recommended dose reductions for adverse reactions are outlined in Table 1. If adverse reactions occur, a maximum of two dose reductions are permitted. Permanently discontinue Adagrasib in patients who are unable to tolerate 600 mg once daily.
The recommended dosage modifications for adverse reactions are provided in Table 2.
FDA,2022.12
