Your Health, We Care
Release date: 2024-08-13 17:50:59 Recommended: 112
Venetoclax is the only approved selective inhibitor of Bcl-2 in the world. By binding Bcl-2 protein with high affinity, Bax/Bak-dependent apoptosis is induced and platelet damage is reduced. The FDA has approved venetoclax for the treatment of CLL, SLL, and in combination with other agents for the treatment of AML.
Patients should be aware of the indications for the drug before purchasing and using it:
Venetoclax is a targeted drug indicated for the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
This type of blood cancer usually develops slowly, but in some cases, it may enter a blast crisis phase and worsen symptoms. By inhibiting the function of BCL-2 protein, venetoclax promotes the normal apoptosis of cancer cells, slows down the progression of the disease, and improves the quality of life of patients.
Before purchasing and following the doctor's instructions, patients should have an understanding of the dosage of the drug, which is organized according to the drug instructions as follows:
Patients with chronic lymphocytic leukemia are typically treated with venetoclax on a 5-week ascending dose regimen to gradually reduce tumor burden and reduce the risk of tumor lysis syndrome (TLS).
The dosage schedule is as follows: 20 mg daily in week 1, 50 mg daily in week 2, 100 mg daily in week 3, and 200 mg daily in week 4. By week 5 and thereafter, patients are given 400 mg orally daily.
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[Warm tips] During the medication, patients should be regularly assessed and monitored by a doctor to keep a close eye on their physical condition.
