Your Health, We Care
Release date: 2024-12-06 14:12:26 Recommended: 84
(1) In order to reduce the potential risk of severe hepatotoxicity in patients, the aminotransferase and total bilirubin levels of patients should be monitored monthly before starting treatment and within the first 12 months of treatment, and then every 3 months during the treatment period of this drug.
(2) It is recommended that patients with hepatotoxicity symptoms, such as nausea, vomiting, right upper quadrant pain, fatigue, anorexia, jaundice, dark urine, fever or itching, immediately stop the drug and seek medical attention, if the patient's aminotransferase level changes during the treatment, suspend the dosing and monitor the patient, and only when the aminotransferase and bilirubin levels return to the pretreatment level, and patients without any symptoms, can consider resuming the drug.
(3) Patients with elevated aminotransferases (more than 3 times the upper limit of normal) may have an increased risk of severe hepatotoxicity, and the use of this drug should be avoided.
(1) Female patients need to take a pregnancy test and confirm that it is negative before taking the drug, and a pregnancy test is required every month during the treatment period and one month after stopping the drug.
(2) It is recommended that female patients of reproductive potential take effective contraceptive measures before starting treatment, during treatment and within one month after stopping the drug.
(1) For patients who may develop hypotension, discontinuation of endothelin receptor antagonists or adjustment to other antihypertensive drugs should be considered, and blood volume should be maintained.
(2) If the patient has hypotension, the dosage of other antihypertensive drugs should be stopped or reduced, and the dose of this drug should be reduced or the administration should be suspended.
(1) The initial dose of sparsentan is 200 mg orally once a day, if the patient can tolerate it, the dose is increased to 400 mg once a day after 14 days, and the doctor should tell the patient to take the whole tablet with water before breakfast or dinner
(2) When the drug is suspended and the drug is resumed again, the drug dose should be adjusted to give the patient an initial dose of 200mg once a day, and after 14 days, the dose should be increased to 400mg once a day.
If you miss a dose, take the next dose at the prescribed time, do not double the dose or exceed the recommended dose
