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Drug interactions of Selpercatinib

1.Effect of Other Drugs on selpercatinib

Strong and Moderate CYP3A Inducers

Concomitant use of selpercatinib with a strong or moderate CYP3A inducer decreases pemigatinib plasma concentrations, which may reduce the efficacy of selpercatinib. Avoid concomitant use of strong and moderate CYP3A inducers with
selpercatinib.

Strong and Moderate CYP3A Inhibitors

Concomitant use of a strong or moderate CYP3A inhibitor with selpercatinib increases pemigatinib plasma concentrations, which may increase the incidence and severity of adverse reactions. Avoid concomitant use of strong and moderate CYP3A inhibitors with selpercatinib. Reduce selpercatinib dosage if concomitant use of strong and moderate CYP3A inhibitors cannot be avoided.

from FDA，2024.06