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In Combination with Bortezomib and Dexamethasone (XVd).The recommended dosage of Selinexor is 100 mg taken orally once weekly on Day 1 of each week until disease progression or unacceptable toxicity in combination.
The recommended dosage of Selinexor is 60 mg taken orally on Days 1 and 3 of each week until disease progression or unacceptable toxicity.
Recommended Selinexor dosage reduction steps are presented in Table 1.
Table 1: Selinexor Dosage Reduction Steps for Adverse Reactions
Recommended dosage modifications for hematologic adverse reactions in patients with multiple myeloma and DLBCL are presented in Table 2 and Table 3, respectively. Recommended dosage modifications for nonhematologic adverse reactions are presented in Table 4.
Table 2: Selinexor Dosage Modification Guidelines for Hematologic Adverse Reactions in Patients with Multiple Myeloma
Table 3: Selinexor Dosage Modification Guidelines for Hematologic Adverse Reactions in Patients with Diffuse Large B-Cell Lymphoma
Table 4: Selinexor Dosage Modification Guidelines for Non-Hematologic Adverse Reactions
from FDA，2022.07
