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Adverse reactions of Pralsetinib

The most common adverse reactions (≥ 25%) were musculoskeletal pain, constipation, hypertension, diarrhea, fatigue, edema, pyrexia and cough.

The most common Grade 3-4 laboratory abnormalities (≥ 2%) were decreased lymphocytes, decreased neutrophils, decreased hemoglobin,  decreased phosphate, decreased leukocytes, decreased sodium, increased  aspartate aminotransferase (AST), increased alanine aminotransferase  (ALT), decreased calcium (corrected), decreased platelets, increased alkaline phosphatase, increased potassium, decreased potassium and  increased bilirubin.

from FDA,2024.03

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