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Drug interactions of Pemigatinib

1.Effect of Other Drugs on pemigatinib

Strong and Moderate CYP3A Inducers

Concomitant use of pemigatinib with a strong or moderate CYP3A inducer decreases pemigatinib plasma concentrations [see Clinical Pharmacology (12.3)], which may reduce the efficacy of pemigatinib. Avoid concomitant use of strong and moderate CYP3A inducers with pemigatinib.

Strong and Moderate CYP3A Inhibitors

Concomitant use of a strong or moderate CYP3A inhibitor with pemigatinib increases pemigatinib plasma concentrations [see Clinical Pharmacology (12.3)], which may increase the incidence and severity of adverse reactions. Avoid concomitant use of strong and moderate CYP3A inhibitors with pemigatinib. Reduce pemigatinib dosage if concomitant use of strong and moderate CYP3A inhibitors cannot be avoided.

from FDA，2022.08