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Are the side effects of osimertinib serious?

Release date: 2025-03-07 11:52:52     Recommended: 97

Osimertinib is a targeted therapy that plays an important role in the treatment of non-small cell lung cancer, but its side effects are also worthy of concern for patients and doctors.

Are the side effects of osimertinib serious?

Understanding the possible side effects of osimertinib and what to do to manage it is important for patients who are receiving this medication.

Common skin reactions

Rash is one of the most common adverse reactions during the administration of osimertinib, with an incidence of between 34% and 43%. This rash is usually mild and is tolerated by most patients. For the few people who develop a severe rash, anti-allergy medications may be considered, and daily skin care routines, such as wearing soft clothing to avoid skin irritation.

Digestive discomfort

Diarrhea is also a common problem among osimertinib users, occurring in about 33% to 47%. Mild diarrhea usually doesn't require special treatment and can be relieved by adjusting dietary habits. However, if diarrhea is severe, you need to seek medical attention and take appropriate measures according to your doctor's advice.

Concerns about cardiac function

Studies have shown that approximately 4.4% of patients may develop cancer-related cardiac insufficiency after osimertinib treatment. This means that regular monitoring of heart function is especially important for patients with a history of heart disease or other cardiovascular risk factors.

How to deal with the side effects of osimertinib

In the face of the side effects of osimertinib, reasonable management and preventive measures can help reduce the burden on patients.

Skin care strategies

In order to reduce the occurrence of rashes or relieve symptoms, patients should maintain good personal hygiene, choose gentle, non-irritating cleaning products, and increase the frequency of moisturizers.

Diet and lifestyle adjustments

To cope with digestive discomfort such as diarrhoea, patients should focus on eating a healthy diet, avoiding greasy, spicy foods, and ensuring adequate fluid intake to prevent dehydration.

Maintenance of heart health

Given the potential cardiotoxicity of osimertinib, patients who are older, have a history of heart failure, or are at risk for other heart diseases should monitor their heart condition more closely and follow their doctor's instructions for necessary investigations and evaluations.

By understanding the side effects of osimertinib and managing them accordingly, patients are able to enjoy the therapeutic effects of the drug while minimizing the impact of adverse reactions. Proper lifestyle modifications, regular medical follow-up, and a positive attitude are all key to helping patients better cope with the challenges of treatment. Every patient's situation is unique, so it is important to communicate with the medical team in a timely manner to develop a personalized solution when experiencing any side effects.