Your Health, We Care
Release date: 2025-03-11 10:54:24 Recommended: 81
Understanding what to look out for during zotuximab can help patients better manage the treatment process, reduce side effects, and improve treatment outcomes.
Zotuximab needs to be dissolved using 5.0 ml of water for injection as prescribed by the Japanese Pharmacopoeia, and the drug concentration after dissolution is 20 mg/ml. When dissolving, it should be kept sterile, injected slowly along the inner wall of the vial, not shaking, and should be stirred slowly until it is completely dissolved. Once dissolved, let it sit until the air bubbles in the vial disappear and avoid direct sunlight.
The dissolved liquid should be a clear liquid that is colorless to slightly yellow. The required amount is drawn from the vial and added to the infusion bag of normal saline to reach a diluted concentration of 2.0 mg/ml. Gently pour the mixed infusion bag so that the solution does not bubble. During the whole process, be careful not to expose to direct sunlight, and visually confirm whether there are particles in the diluted liquid, and do not use when particles are found.
Zortuximab can cause allergic reactions, including severe reactions such as rash, itching, shortness of breath, laryngeal edema, and anaphylactic shock. Mild nausea and vomiting can be relieved by adjusting the diet and using antiemetic medications. For patients with severe symptoms, they should seek medical attention and take appropriate treatment measures.
An in-depth understanding of the application details of zotuximab and its market performance will help to make better use of this new anti-cancer drug.
Zortuximab is indicated for the treatment of Claudin18.2-positive and unresectable advanced recurrent gastric cancer. The drug inhibits tumor cell growth and prolongs patient survival by specifically binding to Claudin18.2 protein.
Zotuximab is recommended only in pregnant women if the benefit of treatment is considered to outweigh the risk of disease. Breastfeeding is not recommended for breastfeeding women during use, as there is a lack of sufficient research data to confirm whether its ingredients enter the milk and affect the baby. There are no relevant clinical trial data for pediatric patients, and it is recommended to use it under the guidance of a doctor.
The original drug produced by Astellas Japan contains 100 mg per bottle and costs about $1,482 per box. Although the drug is not yet available in China, a generic version is available on the market. When choosing a drug, you should pay attention to checking the authenticity and expiration date of the drug.
Zottuximab is a targeted therapy that has shown great potential in the treatment of specific types of cancer. Correctly understanding and managing the precautions for the use of this drug, and following the doctor's instructions for personalized treatment, is the key to improving the effectiveness of treatment. At the same time, paying attention to the correct storage conditions and expiration date of drugs can help ensure that the effect of medication is maximized. For patients considering zotuximab regimens, it is important to have adequate drug information and work closely with the care team to develop a treatment plan that works best for them.
