Your Health, We Care
Release date: 2026-01-26 17:37:21 Recommended: 16
In addition to the intended effects, medications may cause some adverse reactions. Although not all of these side effects may occur, medical attention may be required if they do appear.
Its approval was based on a non-randomized, dose-finding and activity-evaluating, multi-cohort, multicenter Phase Ⅰ/Ⅱ clinical trial (Study No.: B7461001). The purpose of this study was to evaluate the efficacy of lorlatinib in the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who had previously received one or more anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK TKIs).
The study divided patients into different subgroups according to prior treatment regimens, with a total of 215 patients with ALK-positive metastatic NSCLC enrolled. The results showed that the objective response rate (ORR) of the patients reached 48% (95% confidence interval: 42%, 55%); notably, 57% of the patients had previously received two or more ALK TKI treatments.
In addition, 69% of the patients in this trial had a history of brain metastases, with an intracranial objective response rate of 60% (95% confidence interval: 49%, 70%).
Contact your doctor immediately if you experience any side effects. Common side effects include loss of behavioral control, aggressiveness, agitation, anxiety, black tarry stools, bleeding gums, blood in urine or stool, blurred vision or other visual changes, body pain, as well as burning, crawling, itching, numbness, tingling, "pins and needles" sensation, or pain in the skin.
In addition, the following symptoms may also occur: behavioral changes, chills, cough, impairment in intelligence, short-term memory, learning ability and concentration, difficulty or labored breathing, depression, dizziness, dry mouth, ear congestion, false or unusual sense of well-being, feeling sad or empty, fever, flushing or dryness of the skin, fruity breath odor, headache, hoarseness, increased appetite or thirst, increased frequency of urination, irritability, loss of appetite, loss of interest or pleasure in things, loss of voice, pain in the lower back or side, nausea, nervousness, pain or difficulty in urination, paleness of the skin, pinpoint red spots on the skin, pounding sensation in the ears, runny or stuffy nose, seeing, hearing or feeling things that are not there, skin rash, slow or fast heartbeat, sneezing, sore throat, stomach pain, sweating, swelling, excitement of speech, sensation and behavior, suicidal thoughts, tightness in the chest, trouble concentrating, trouble sleeping, shortness of breath, unexplained weight loss, unsteadiness or clumsiness, unusual bleeding or bruising, unusual tiredness or weakness, vomiting, and weakness of the arms, hands, legs or feet. Seek medical help promptly if any of the above manifestations occur.
Take the medication to a drug take-back program. Consult your pharmacy or law enforcement agency to find a take-back location.
If the medication cannot be returned, check the label or package insert to see if it should be discarded in the trash or flushed down the toilet. If you are unsure, consult your healthcare team.
If it is safe to put it in the trash, remove the medication from its container. Mix the medication with cat litter, dirt, coffee grounds, or other undesirable substances. Seal the mixture in a bag or container, then place it in the trash.
