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Lenvatinib is an oral targeted therapy indicated for the treatment of radioactive iodine-refractory differentiated thyroid carcinoma (RAI-RDTC). Below is a summary of its dosage and administration:
Take once daily at a fixed time, either with food or on an empty stomach.
There are three administration options:
Swallow the capsule whole (preferred method);
Dissolve in water or apple juice for oral intake (for patients unable to swallow the capsule whole);
Administer via feeding tube (for patients requiring tube feeding).
The standard dosage is 24 mg per day. The specific dosage must be determined by the physician based on the patient’s individual condition.
The daily dosage may consist of a combination of multiple capsules (e.g., a mix of 10 mg and 4 mg strengths).
If a dose is missed, take the missed dose as soon as possible.
If it is almost time for the next scheduled dose (less than 12 hours remaining until the next dose), skip the missed dose and take the next dose as originally planned.
In case of overdose, contact a physician immediately or proceed to the emergency department for medical attention.
Dissolution in Liquid for Oral Intake
Place the total daily dosage (maximum 5 capsules) into a container or oral syringe;
Add 3 mL of water or apple juice;
Allow 10 minutes for the capsule shells to dissolve, then stir or shake vigorously for 3 minutes to ensure complete dissolution;
Drink the mixture. Rinse the container with an additional 2 mL of liquid, drink the rinse solution, and repeat this step until no residue remains.
Administration via Feeding Tube
Dissolve the capsules in water following the steps above;
Administer the solution via a feeding tube of at least 5 French (PVC/polyurethane) or 6 French (silicone) caliber;
Flush the tube thoroughly after administration to ensure no residue is left.
Store at 20°C to 25°C. Keep out of reach of children.
If surgery (including dental procedures) is required during treatment, discontinue Lenvatinib at least 1 week in advance, and resume administration only under the guidance of a physician.
Regular monitoring of blood pressure, liver function, renal function, thyroid function, and other relevant parameters is necessary.
Contact a physician immediately if severe adverse reactions occur, such as hypertension, palpitations, bleeding, abdominal pain, etc.
from FDA，2024.06
