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Release date: 2026-04-09 13:37:00 Recommended: 9
Like other medicines, larotrectinib may cause adverse reactions.
Very common adverse reactions (affecting more than 1 in 10 people) include: dizziness, anemia (manifesting as pale complexion and palpitations), influenza-like symptoms with fever, nausea, vomiting, diarrhea, constipation, muscle pain, fatigue, elevated liver enzymes, and weight gain.
Common adverse reactions (affecting up to 1 in 10 people) include: easy bruising or bleeding (indicating thrombocytopenia), taste disturbance, and muscle weakness.
Elevated alkaline phosphatase levels are very common in pediatric patients.
You must inform your doctor immediately if you experience any of the following: tingling, numbness or burning sensation in the hands and feet, difficulty walking; or symptoms suggestive of liver problems such as fatigue, right upper abdominal pain, loss of appetite, yellowing of the skin and eyes, and dark urine.
Keep larotrectinib out of the sight and reach of children to prevent accidental ingestion.
This medicinal product does not require any special storage conditions (e.g., refrigeration). Do not use after the expiry date (EXP) printed on the carton and plastic bottle. The expiry date refers to the last day of that month.
Do not use the capsules if you notice any signs of breakage, cracks or other damage before use.
Do not dispose of unused or expired medicinal products via wastewater, toilet or general household waste. Consult your pharmacist about the proper disposal method for medicinal residues to protect the environment.
For pediatric patients requiring Lucius Pharmaceuticals larotrectinib, the doctor will calculate the precise dose for each administration based on the child’s height and weight. The medicine is given twice daily, and the maximum recommended dose per administration shall not exceed 100 mg.
If the child is unable to swallow hard capsules, an oral solution formulation is available from the manufacturer as an alternative.
A very common adverse reaction in children is elevated blood levels of alkaline phosphatase, which is usually asymptomatic but will be regularly monitored by the doctor.
Parents should carefully observe the child for abnormal fatigue, unsteady gait or mood changes, and communicate with the doctor promptly.
If the child vomits or misses a dose, do not make up for the missed dose or administer a double dose. Simply take the next dose at the usual scheduled time.
