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Crizotinib is suitable for the treatment of locally advanced or metastatic NSCLC with ALK positivity, as well as NSCLC diseases with ROS1 positivity. It is a tyrosine kinase inhibitor (TKI) that plays a therapeutic role in treating patients with advanced non-small cell lesions that are ALK positive and certain MET amplifications. Clozotinib inhibits the activity of certain specific tyrosine kinases, blocks cellular signaling pathways, and inhibits the growth and spread of diseased cells.
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