Your Health, We Care
Release date: 2024-11-21 16:01:14 Recommended: 81
The FLT3 inhibitor Gilteritinib (Xospata) has resulted in significant survival improvements in patients with relapsed/refractory acute myeloid leukemia (AML) harboring FLT3 mutations.
Median overall survival (OS) and complete response/complete response with partial hematologic recovery (CR/CRh) were nearly doubled in adult patients with relapsed/refractory FLT3-mutant acute myeloid leukemia compared with chemotherapy.
Specifically, patients randomized to geritinib had a median OS of 9.3 months (95% CI 7.7-10.7 months) compared to 5.6 months (95% CI 4.7-7.3 months) for patients receiving chemotherapy. This represents a 36% reduction in the risk of death with gilitinib (hazard ratio 0.637; The 95% confidence interval is 0.490-0.830; P
= .007)。 At the same time, the CR/CRh rate reached 34% in the gilitinib group, which was much higher than the 15% in the chemotherapy group.
Common side effects of gilitinib include cytopenias, anemia, neutropenia, thrombocytopenia, and abnormally elevated liver function tests (LFTs). It is important to note that these side effects are asymptomatic in most cases. The efficacy and safety data of gilitinib provide strong support for its use in the treatment of relapsed/refractory AML.
Gilitinib may cause liver problems such as elevated aminotransferases, elevated bilirubin levels, and more. If you have symptoms, you should seek medical attention and inform your doctor immediately.
Renal impairment is a common kidney problem, with an overall incidence of 19%, including acute kidney injury, elevated serum creatinine and other manifestations.
Gireltinib may cause abnormal blood pressure, including hypertension (10%) and hypotension (30%). If you have symptoms, you should inform your doctor immediately.
Metabolic problems such as hyperglycemia (86%), hypocalcemia (61%), and hyponatremia (32%) may also occur.
Patients should pay close attention to their body changes while taking giritinib, have regular check-ups, and report any discomfort to their doctor.
Based on your doctor's advice, if you experience serious side effects or intolerance, consider adjusting the dose or stopping the drug.
Some side effects, such as nausea, vomiting, diarrhea, etc., can be relieved with adjuvant drugs under the guidance of a doctor.
