1. Interstitial Lung Disease (ILD).
2. Renal Failure.
3. Hepatotoxicity (with or without hepatic impairment).
4. Gastrointestinal Perforation.
5. Bullous and Exfoliative Skin Disorders.
6. Cerebrovascular Accident.
7. Thrombotic Microangiopathic Hemolytic Anemia with Thrombocytopenia.
8. Ocular Disorders.
9. Bleeding in Patients Taking Warfarin.
FDA,2016.10