Your Health, We Care
Release date: 2026-03-09 16:37:13 Recommended: 9
Lucius Pharmaceuticals Entrectinib is a targeted anticancer drug primarily used to treat solid tumors and lymphomas carrying specific gene mutations. Common side effects include fatigue, dizziness, and constipation; in severe cases, it may cause liver damage or heart problems. Strict adherence to doctor's instructions and regular monitoring of relevant indicators are essential during treatment.
Gastrointestinal Reactions: Such as constipation, nausea, diarrhea, and decreased appetite, which can usually be relieved by adjusting diet or medication.
Nervous System Symptoms: Dizziness, headache, and paresthesia (such as numbness or tingling) are relatively common, mostly mild to moderate.
Systemic Malaise: Fatigue, weakness, muscle or joint pain, which may affect daily activities.
Metabolic Abnormalities: May cause elevated serum creatine kinase and hypophosphatemia, requiring regular electrolyte monitoring.
Liver Damage: Manifests as jaundice, dark urine, and abdominal pain, requiring monitoring of transaminase and bilirubin levels through liver function tests.
Cardiotoxicity: Includes QT interval prolongation, arrhythmia, and heart failure, potentially causing symptoms such as chest pain and dyspnea.
Neurotoxicity: Such as severe peripheral neuropathy or cognitive impairment (memory loss, confusion).
Visual problems: Blurred vision or flashes of light, possibly related to retinopathy.
Weight changes: Some patients experience significant weight gain or loss.
Allergic reactions: Rare but should be monitored, such as rash, itching, and facial swelling.
Dosage adjustment as directed by your doctor: Depending on the severity of side effects, your doctor may suspend, reduce, or discontinue treatment.
Drug interactions: Avoid concomitant use with potent CYP3A4 inhibitors or inducers, as this may affect efficacy or toxicity.
Special populations: Contraindicated in pregnant women (risk to the fetus); breastfeeding should be discontinued during lactation.
During treatment, liver function tests, electrocardiograms, and complete blood counts should be performed every 2-4 weeks. If persistent vomiting, difficulty breathing, severe headaches, or palpitations occur, contact your doctor immediately. Do not adjust the medication regimen or dosage on your own.
