Common side effects of Crizotinib and daily precautions

Release date: 2026-05-19 15:59:03     Recommended: 10

Common side effects of Crizotinib and daily precautions

The most common side effect in adult NSCLC patients taking Crizotinib is visual changes, which occur 4 to 7 times per week in most patients, each episode usually lasting less than 1 minute, with little or no impact on daily activities. Other common side effects include: nausea, diarrhea or vomiting; swelling of the hands, feet, face, or eyes; constipation; elevated liver function indicators; fatigue; decreased appetite; upper respiratory infection; dizziness; numbness or tingling in the arms or legs. Because the drug may cause visual changes, dizziness, and fatigue, patients should avoid driving or operating machinery when experiencing these symptoms. Additionally, Crizotinib can increase skin photosensitivity; prolonged sun exposure should be avoided during treatment, and sunscreen and protective clothing should be used when going outdoors. This drug may also affect fertility in both men and women.

Liver and lung-related risks of Crizotinib

Crizotinib may cause life-threatening serious side effects. First is liver injury: this drug may cause severe hepatotoxicity, even fatal. Therefore, during the first 2 months of treatment, healthcare providers should perform blood tests every 2 weeks to monitor liver function, then monthly thereafter. If new or worsening symptoms such as yellowing of the skin or whites of the eyes, severe fatigue, dark tea-colored urine, nausea/vomiting, decreased appetite, right-sided abdominal pain, unusual bleeding or bruising, or skin itching occur, seek medical attention immediately. Second is lung problems (pneumonitis): Crizotinib may cause interstitial lung disease, with symptoms similar to lung cancer itself, including difficulty breathing or shortness of breath, cough (with or without phlegm), and fever. If these symptoms occur, also inform your doctor immediately.

Heart problems and severe visual impairment related to Crizotinib

Crizotinib may cause slow, fast, or irregular heartbeat (such as QT prolongation). During treatment, your doctor may monitor your pulse and blood pressure. If you experience dizziness, fainting, or abnormal heartbeat sensation, report it immediately. If you are taking other heart or blood pressure medications, also inform your doctor. Furthermore, visual problems are an extremely common side effect of Crizotinib, typically occurring within the first week of treatment. Although most are mild, they may develop into serious issues, even leading to partial or complete loss of vision in one or both eyes. If you experience any visual changes such as double vision, seeing flashes of light, blurred vision, light sensitivity, new or increased floaters, tell your doctor immediately; your doctor may suspend or discontinue treatment and refer you to an eye specialist.