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Adverse reactions of Crizotinib

The most common adverse reactions (≥25%) in adult patients with NSCLC are vision disorders, nausea, diarrhea, vomiting, edema, constipation, elevated  transaminases, fatigue, decreased appetite, upper respiratory infection,  dizziness, and neuropathy.

The most common adverse reactions (≥35%) in patients with ALCL are  diarrhea, vomiting, nausea, vision disorder, headache, musculoskeletal pain,  stomatitis, fatigue, decreased appetite, pyrexia, abdominal pain, cough, and  pruritus. Grade 3-4 laboratory abnormalities (≥15%) are neutropenia, lymphopenia, and thrombocytopenia.

The most common adverse reactions (≥35%) in adult patients with IMT are  vision disorders, nausea, and edema.The most common adverse reactions (≥35%) in pediatric patients with IMT are vomiting, nausea, diarrhea, abdominal pain, rash, vision disorder, upper  respiratory tract infection, cough, pyrexia, musculoskeletal pain, fatigue,  edema, constipation, and headache.

from FDA，2023.09