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Release date: 2025-04-02 11:46:02 Recommended: 45
This article discusses the standardized use and precautions of the drug crizotinib.
Reasonable drug dosage control is the key to achieving therapeutic efficacy.
Adults are recommended to take 250mg capsules twice daily. Clinical studies have shown that this dose can better control the pathological progression of specific diseases while maintaining the balance of blood concentration. For special 200mg capsules, the number of capsules taken at a time should be adjusted according to the doctor's instructions.
When liver function is abnormal or drug metabolism is impaired, the dose needs to be lowered to 200 mg per day. Some patients may have visual disturbances or gastrointestinal reactions, and a phased dose reduction should be performed under the guidance of a physician. Regular ECG reviews are required during treatment to prevent the potential risk of QT interval prolongation.
For patients who have been on treatment for more than 12 months, quarterly metabolic function assessment is recommended. The drug should be stored away from light and moisture, and the capsule should be used within 30 days after opening. The market price of a single box (60 capsules) is about $130, and there are price differences between different packaging specifications.
Scientific drug use needs to consider many factors.
It is contraindicated in pregnant women and in patients with severe hepatic dysfunction. Patients who are receiving other targeted therapies should wait at least 48 hours before starting this drug regimen. Patients who are lactose intolerant should inform their treating physician in advance.
Capsules should be swallowed whole, with warm water for best results. It is recommended to fix the daily time of medication, and the interval between the two doses is strictly maintained for 12 hours. If the dose is missed, it can be retaken within 4 hours, and the current dose should be skipped.
Imaging evaluation is performed every 6 weeks at the beginning of treatment, and the stabilization period is extended to every 12 weeks. Blood tests should focus on neutrophil count and aminotransferase levels. Some patients may present with fatigue symptoms, which usually resolve gradually after 2 to 3 weeks.
Standardized medication requires close cooperation between doctors and patients, and a complete management system is formed from dose control to process monitoring. Through an individualized treatment plan and regular medical evaluation, the effect of the drug can be maximized and the patient can achieve a good prognosis.
