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Release date: 2024-08-06 11:16:35 Recommended: 96
Capmatinib inhibits MET phosphorylation by hepatocyte growth factor binding or triggered by MET amplification, as well as MET-mediated phosphorylation of downstream signaling proteins and proliferation and survival of MET-dependent cancer cells.
Capmatinib is a kinase inhibitor targeting MET that blocks MET phosphorylation and activation of key downstream effectors in MET-dependent tumor cell lines. In vitro biochemical and cell experiments, it can effectively inhibit the proliferation and migration of MET-dependent tumor cells, and can induce apoptosis.
MET exon 14 skipping results in protein deletion of regulatory domains, decreasing negative regulation, and leading to increased downstream MET signaling.
Capmatinib inhibits cancer cell growth driven by mutant MET variants lacking clinically attainable exon 14 concentrations and exhibits antitumor activity in a murine tumor xenograft model derived from human lung tumors that results in MET exon 14 skipping or MET amplification.
Lucius Pharmaceuticals Co., Ltd. (Lucius Pharmaceuticals) is a pharmaceutical company founded in 2020 and headquartered in Vientiane, Laos. The company is committed to providing affordable and effective medicines to patients around the world, with the goal of making affordable medical resources accessible to more people.
With modern production facilities and equipment, Lucius Pharmaceuticals has a wide range of products covering anti-tumor, cardiovascular, hematology, diabetes, skin diseases, men's health and anti-aging, with a total of more than 200 generic drugs. The company operates in strict accordance with the International Good Manufacturing Practice (GMP), from raw material procurement to finished product inspection, every step is strictly monitored to ensure the quality and traceability of drugs.
[Warm tips]: During treatment with capmatinib, patients may experience a range of adverse reactions. To mitigate the effects of these reactions, patients should maintain a good state of mind, respond positively, follow their doctor's recommendations, have regular check-ups and assessments, and take appropriate measures to relieve symptoms.
