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Dosage of Capmatinib

1.Patient Selection

Select patients for treatment with Capmatinib based on the presence of a mutation that leads to MET exon 14 skipping in  tumor or plasma specimens. If a mutation that leads to MET exon 14 skipping is not detected  in a plasma specimen, test tumor tissue if feasible. 

2.Recommended Dosage

The recommended dosage of Capmatinib is 400 mg orally twice daily with or without food.  Swallow Capmatinib tablets whole. Do not break, crush or chew the tablets.  If a patient misses or vomits a dose, instruct the patient not to make up the dose, but to take the next dose at its scheduled  time.

3.Dosage Modifications for Adverse Reactions

The recommended dose reductions for the management of adverse reactions are listed in Table 1.

Permanently discontinue Capmatinib in patients who are unable to tolerate 200 mg orally twice daily.  

The recommended dosage modifications of Capmatinib for adverse reactions are provided in Table 2.

from FDA,2023.03