Your Health, We Care
Release date: 2026-03-20 17:04:04 Recommended: 43
Cabozantinib is a broad‑spectrum multi‑targeted anticancer drug that inhibits at least 9 targets, including MET, VEGFR1/2/3, ROS1, RET, AXL, NTRK, and KIT.
Seek immediate medical attention if any of the following side effects occur while taking cabozantinib:
(1) Blurred vision, burning, numbness, tingling, or pain; confusion; constipation; dark urine; skin discoloration; decreased urine output; diarrhea; difficulty breathing or swallowing; headache; dry mouth; dry skin and hair; fainting; feeling cold;
(2) Hair loss; headache; hoarseness; rapid heart rate; lightheadedness; loss of appetite; mood depression; muscle spasms, twitching, and stiffness; nausea or vomiting; nervousness; pain in the chest, groin, or legs (especially calves); ringing in the ears; shortness of breath;
(3) Red, swollen, or painful skin; peeling skin on palms and soles; severe, sudden headache; rash or sores; slow or fast heartbeat; slurred speech; stomach pain; sudden loss of coordination; sudden severe weakness or numbness in the arm or leg; sunken eyes;
(4) Thirst; unsteady walk or clumsiness; unusual tiredness or weakness; vision changes; weakness in the arms, hands, legs, or feet; weight gain; wrinkled skin; yellowing of the eyes or skin.
(1) Bleeding gums; bloody, black, or tarry stools; coughing up blood; heartburn; heavy feeling in the jaw; increased menstrual flow or vaginal bleeding; indigestion; loose teeth; mood or mental changes; muscle spasms in the hands, arms, feet, legs, or face;
(2) Nosebleeds; numbness and tingling around the mouth, fingertips, or feet; pain, swelling, or numbness in the mouth or jaw; paralysis; prolonged bleeding from wounds; red or dark brown urine;
(3) Seizures; severe stomach pain, cramps, or burning; tremors; trouble breathing; severe and persistent vomiting that resembles coffee grounds.
Abnormal color vision; double vision; halos around lights; night blindness; sensitivity to light; tunnel vision.
Consult a healthcare professional if any of the following side effects persist, are bothersome, or if you have questions about them:
(1) Belching; bleeding after bowel movements; altered taste; changes in hair color; decreased appetite; weight loss; difficulty having a bowel movement; difficulty moving; fear; tiredness or loss of strength;
(2) Loss of taste; muscle pain; joint pain; rash; sore throat; stomach discomfort, upset, or pain; swelling or inflammation of the mouth; uncomfortable swelling around the anus; voice changes.
Very common: Elevated alanine aminotransferase (ALT), elevated aspartate aminotransferase (AST), increased alkaline phosphatase, hyperbilirubinemia.
Common: Cholelithiasis.
Uncommon: Hepatic encephalopathy.
Very common: Diarrhea, stomatitis, nausea, oral pain, constipation, abdominal pain, vomiting, dysphagia, dyspepsia, glossalgia.
Common: Hemorrhoids, gastrointestinal perforation, gastrointestinal fistula, gastrointestinal hemorrhage, pancreatitis, anal fissure, anal inflammation, cheilitis.
Uncommon: Esophagitis.
Very common: Increased blood thyroid-stimulating hormone.
Common: Hypothyroidism, adrenal insufficiency.
Uncommon: Amenorrhea.
Very common: Lymphopenia, neutropenia, thrombocytopenia.
Uncommon: Increased eosinophil count, increased platelet count.
Post-marketing reports: Aneurysms (including aorta), arterial dissection, and arterial rupture.
Very common: Palmar‑plantar erythrodysesthesia syndrome, hair color changes/depigmentation/graying, dry skin, alopecia, erythema.
Common: Hyperkeratosis, folliculitis, acne, blisters, abnormal hair growth, skin desquamation, skin hypopigmentation.
Uncommon: Skin ulcer, telangiectasia.
Very common: Weight loss, decreased appetite, hypocalcemia, hypophosphatemia, hypomagnesemia, hypokalemia, hyponatremia, increased blood lactate dehydrogenase, increased blood creatine phosphokinase.
Common: Dehydration, hypoalbuminemia.
Very common: Dysgeusia, headache, dizziness.
Common: Paresthesia, peripheral sensory neuropathy, peripheral neuropathy, ageusia, tremor.
Uncommon: Posterior reversible encephalopathy syndrome, ataxia, disturbance in attention, loss of consciousness, speech disorder, transient ischemic attack.
Very common: Arthralgia, muscle spasms.
Common: Musculoskeletal chest pain, osteonecrosis of the jaw (ONJ).
Uncommon: Rhabdomyolysis.
Very common: Increased blood pressure, hypertension.
Common: Hypotension, venous thromboembolism, arterial thromboembolism, atrial fibrillation.
Uncommon: Angina pectoris, supraventricular tachycardia, shortened activated partial thromboplastin time.
Frequency not known: QT prolongation.
Common: Proteinuria, dysuria, hematuria.
Uncommon: Vaginal bleeding.
Common: Blurred vision.
Uncommon: Cataract, conjunctivitis.
Common: Anxiety, depression, confusional state.
Uncommon: Abnormal dreams, delirium.
Very common: Dysphonia (up to 20%), oropharyngeal pain.
Common: Non-gastrointestinal fistula (including tracheal fistula, mediastinal emphysema, tracheoesophageal fistula), pulmonary embolism, respiratory tract hemorrhage (including lung, bronchus, trachea), pneumonia, aspiration pneumonia.
Uncommon: Atelectasis, pharyngeal edema, pneumonitis.
Very common: Fatigue, asthenia, mucosal inflammation.
Common: Abscess (including visceral, intra-abdominal, skin, dental), fungal infection (including skin, oral, genital), ear pain, tinnitus, pallor, cold extremities, impaired wound healing/wound complications, chills, facial edema.
Uncommon: Aspergilloma, hearing impairment, cyst, facial pain, localized edema.
Frequency not known: Hemorrhage.
Note:
Very common: ≥ 10%
Common: 1% – 10%
Uncommon: 0.1% – 1%
