Your Health, We Care
Release date: 2025-02-26 11:53:16 Recommended: 80
Cabozantinib is a multi-kinase inhibitor that is often used in combination with other drugs in clinical treatment, but its interaction with other drugs is a cause for concern.
Interactions with other drugs may affect the efficacy of cabozantinib and even pose potential risks.
Cabozantinib may increase the risk of bleeding when combined with an anticoagulant drug, such as warfarin. This is because cabozantinib may affect the activity of thrombin, leading to a prolonged clotting time, which can increase bleeding tendency.
When cabozantinib is used in combination with antihypertensive drugs (eg, ACE inhibitors, ARBs), it can cause blood pressure to be too low. Cabozantinib has the effect of inhibiting angiotensin II receptor activity, which may exacerbate the antihypertensive effect of antihypertensive drugs, which in turn can cause hypotensive symptoms.
When cabozantinib is used in combination with chemotherapy drugs (eg, paclitaxel, doxorubicin), it may increase toxicity. This is because cabozantinib may affect the metabolism and excretion of chemotherapy drugs, causing the drug to accumulate in the body, which can increase toxicity.
Understanding and taking appropriate steps can help reduce the risk of cabozantinib interactions with other medications.
Before using cabozantinib, the physician should ask the patient a detailed drug history, including prescription drugs, over-the-counter drugs, health products, etc., so as to detect potential interaction risks in time.
For drugs with known interactions, doctors should adjust the dose of the drug to reduce side effects based on the patient's specific situation. If necessary, consider withholding certain medications.
During the use of cabozantinib, patients should have regular blood routine, liver and kidney function tests, etc., so as to detect adverse reactions caused by drug interactions in time. Doctors should follow up and adjust treatment based on changes in the patient's condition.
The interaction between cabozantinib and other drugs is a problem that cannot be ignored in clinical treatment. For the sake of patient safety, physicians should fully understand the mechanism of cabozantinib interactions and take appropriate measures to reduce the risk. Patients should also actively cooperate with the doctor's treatment recommendations, and have regular monitoring and follow-up to maintain their health.
