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The recommended dosage for brigatinib is:
90 mg orally once daily for the first 7 days; then increase the dose to 180 mg orally once daily.
Administer brigatinib until disease progression or unacceptable toxicity.
If brigatinib is interrupted for 14 days or longer for reasons other than adverse reactions, resume treatment at 90 mg once daily for 7 days before increasing to the previously tolerated dose. brigatinib may be taken with or without food. Instruct patients to swallow tablets whole. Do not crush or chew tablets. If a dose of brigatinib is missed or vomiting occurs after taking a dose, do not administer an additional dose and take the next dose of brigatinib at the scheduled time.
2.Dosage Modifications for Adverse Reactions
brigatinib dosage reductions for adverse reactions are summarized in Table 1.
from FDA，2022.02
