The recommended dosage of Aprocitentan is 12.5 mg orally once daily.
Swallow tablets whole. Aprocitentan may be taken with or without food.
If a dose is missed, skip the missed dose and take the next dose at the regular time. Do not take two doses on the same day.
Initiate treatment with Aprocitentan in females of reproductive potential only after confirmation of a negative pregnancy test. Patients should exclude pregnancy with negative pregnancy tests monthly during treatment and one month after discontinuation of treatment with Aprocitentan.
from FDA,2024.03