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Initiate treatment at 5 mg once daily, which may be used with or without tadalafil 20 mg once daily. At 4-week intervals, the dose of ambrisentan or tadalafil may be increased to ambrisentan 10 mg or tadalafil 40 mg, respectively, based on need and tolerability.
Do not split, crush, or chew the tablets.
Before initiating ambrisentan treatment in females of reproductive potential, pregnancy should be excluded.
FDA，2025.04
